Google’s own AdSense experts say that that there is a direct correlation between the placement of the AdSense ads and the resulting clickthrough.
When ads are placed in “content zones”, rather than in “advertising zones”, response rates on Google AdWords goes up. There are also indications showing that ads appearing on the right side of the page get clicked more than ads appearing on the left side.
Advertising analysts with degrees in human behavior and psychology have spent thousands of man-years (people-years?) studying how people read printed and Internet content and what it takes to get them to respond to ads. While some of these studies are proprietary, or are only available to anyone with $10,000 or more to spend on a copy, other studies have been made public and can be read by anyone who is interested.
Google themselves has released some relevant information which is focused directly on increasing your Google AdSense response. You can read their findings here (https://www.google.com/support/adsense/bin/static.py?page=tips.html).
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